Metabolism Ketamine is metabolized by way of N-dealkylation into the Energetic metabolite norketamine primarily by CYP2B6 and CYP3A4 also to a lesser extent by other CYP enzymes. Norketamine undergoes hydroxylation in the cyclohexone ring to form hydroxynorketamine compounds by means of CYP-dependent pathways, which are conjugated with glucuronic a